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CombiNAber Explanation


We have developed two models, the additive model (Kong et al. 2015) and the Bliss-Hill model (Wagh et al. 2016), that can accurately predict neutralization by antibody combinations using IC50 and/or IC80 data for individual antibodies tested in vitro against a virus panel. The additive model can work with either IC50 or IC80 alone, while the Bliss-Hill model requires both. We have found that while both models are fairly accurate in predicting experimental combination data, the Bliss-Hill model is more accurate, and also allows calculation of other neutralization metrics (see Incomplete neutralization).

Input Data

Analysis Options

Output Data & Analyses

All of the data, figures & analyses generated are available for the user to download as a zip file. Select analyses & figures will be shown on the output page.

last modified: Wed Oct 12 11:58 2016

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