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CombiNAber

A tool for Prediction & Analysis of Neutralization by Antibody Combinations

Purpose: This tool predicts and analyzes combination antibody neutralization scores using IC50 and/or IC80 for individual antibodies. The predicted scores are systematically compared for all single antibodies and 2, 3 and 4 antibody combinations analyzed. See explanation.


IC50/IC80 data
Paste values or upload file

(See assay requirements)
icon

[Sample Input]
'<' and '>' signs are NOT allowed. Please replace them with 'LT' and 'GT' respectively. icon
Data type IC50   IC80   Both
Delimiter Comma   Space   Tab  

mAb class
Paste values or upload file

(See Ab class requirements)
icon
Delimiter Comma   Space   Tab  

Options
Prediction method icon Additive Bliss-Hill
mAb combinations icon Combinations using full set of mAbs
      # of Abs in Ab combination 4  (may be adjusted depending # of Abs)
     Repeat mAbs from same class in combinations
Combinations of interest (example)
  
  
Analyses Target concentration ug/ml (seperate with commas if more than one concentration) icon
Active coverage by multiple mAbs in combination icon
Incomplete neutralization icon
Instantaneous inhibitory potential (IIP) icon
File format for figures PDF  SVG  PNG 
Email results

Reference:

last modified: Tue Sep 27 15:30 2016


Questions or comments? Contact us at seq-info@lanl.gov.

 
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