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Displaying record number 64

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVATL

Epitope Alignment

Variants

SLfNTVATL escape documented in this paper; susceptible form

Epitope Name SL9

Species (MHC/HLA) human(A*02:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`97`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVATL`
Mutations	Y/F
Epitope Location	Y3F
HXB2 Location	Y79F
Mutation Type	E: escape documented in this paper SF: susceptible form
Note	The substitution Y79F was an escape mutation because it interfered with CTL recognition by one CTL clone from an A*0201 infected individual, clone 13010.B17, but it was still recognized by another CTL clone, 115.D4.

References

Brander1999a C. Brander, O. O. Yang, N. G. Jones, Y. Lee, P. Goulder, R. P. Johnson, A. Trocha, D. Colbert, C. Hay, S. Buchbinder, C. C. Bergmann, H. J. Zweerink, S. Wolinsky, W. A. Blattner, S. A. Kalams, and B. D. Walker. Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope Despite Multiple Variations in the Epitope Flanking Sequences. J. Virol., 73:10191-10198, 1999. PubMed ID: 10559335. Show all entries for this paper.