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Found 1 matching record:

Displaying record number 54192

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPtDLNTML   escape documented in this paper
Epitope Name TL9
Species (MHC/HLA human

Variant Details

Showing 1 of 20 variants.


Variant ID.  917
Epitope Seq.  TPQDLNTML
Variant Seq.  TPtDLNTML
Mutations Q/T
Epitope Location Q3T
HXB2 Location Q182T
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant found in B*8101, B*4201 and B*0702 positive patients. The variant was less well recognized than the wt, or not recognized at all, by CTLs from B*8101 and B*4201 positive individuals.

References

Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.


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