HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(151-159)|| Gag Epitope Map
View variants at this location
|Species (MHC/HLA)||human, transgenic mouse(A2)|
Showing 1 of 3 variants.
|Epitope Location||V8A V9I|
|HXB2 Location||V158A V159I|
|Mutation Type||SF: susceptible form|
|Method||CD8 T-cell Elispot - IFNy, Chromium-release assay|
|Note||To identify immunogenically optimized epitopes for use in vaccines, mutants of TV9 were tested in transgenic mice. Natural TV9 mutants tested in transgenic HLA-A*02 mice showed the following responses - the common mutant V9I, TLNAWVKVi was less immunogenic and had low cross-reactivity. TLNAWVKaV (most cross-reactive) and TLNAWVKai were highly immunogenic and cross-reactive to the consensus.|
Blondelle2008 Sylvie E. Blondelle, Rosa Moya-Castro, Keiko Osawa, Kim Schroder, and Darcy B. Wilson. Immunogenically Optimized Peptides Derived from Natural Mutants of HIV CTL Epitopes and Peptide Combinatorial Libraries. Biopolymers, 90(5):683-694, 2008. PubMed ID: 18481808. Show all entries for this paper.