HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 55324

HXB2 Location  Gag(197-205)   Gag Epitope Map
View variants at this location
Epitope AMQMLKDTI   Epitope Alignment
Variants
AMQiLKDTI   diminished response
Epitope Name G
Species (MHC/HLA mouse(H-2Kd)

Variant Details

Showing 1 of 2 variants.


Variant ID.  806
Epitope Seq.  AMQMLKDTI
Variant Seq.  AMQiLKDTI
Mutations M/I
Epitope Location M4I
HXB2 Location M200I
Mutation Type DR: diminished response
Epitope Subtype A, C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clades A or C vaccines, both containing the wt epitope, T cells responded well to the index epitope, and intermediately to this variant.

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health