HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 55324

HXB2 Location  Gag(197-205)   Gag Epitope Map
View variants at this location
Epitope AMQMLKDTI   Epitope Alignment
AMQiLKDTI   diminished response
Epitope Name G
Species (MHC/HLA mouse(H-2Kd)

Variant Details

Showing 1 of 2 variants.

Variant ID.  806
Epitope Seq.  AMQMLKDTI
Variant Seq.  AMQiLKDTI
Mutations M/I
Epitope Location M4I
HXB2 Location M200I
Mutation Type DR: diminished response
Epitope Subtype A, C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note After immunization with Clades A or C vaccines, both containing the wt epitope, T cells responded well to the index epitope, and intermediately to this variant.


Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.

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