HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(77-85)|| Gag Epitope Map
View variants at this location
|Species (MHC/HLA)||human, transgenic mouse(A2)|
Showing 1 of 4 variants.
|Epitope Location||Y3F T5L|
|HXB2 Location||Y79F T81L|
|Mutation Type||SF: susceptible form|
|Method||CD8 T-cell Elispot - IFNy, Chromium-release assay|
|Note||To identify immunogenically optimized epitopes for use in vaccines, mutants of SL9 were tested in transgenic mice. SLYNTVATL and most common mutant, SLfNTVATL, were weakly immunogenic or cross-reactive. 3 mutants, SLYNlVATL, SLfNlVATL and SiYNlVATL were highly immunogenic. Peptide SiYNlVATL with the additional L2I change allowed great cross-reactivity to the consensus.|
Blondelle2008 Sylvie E. Blondelle, Rosa Moya-Castro, Keiko Osawa, Kim Schroder, and Darcy B. Wilson. Immunogenically Optimized Peptides Derived from Natural Mutants of HIV CTL Epitopes and Peptide Combinatorial Libraries. Biopolymers, 90(5):683-694, 2008. PubMed ID: 18481808. Show all entries for this paper.