HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 55763

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
SLYNlVATL   susceptible form
Epitope Name SL9
Species (MHC/HLA human, transgenic mouse(A2)

Variant Details

Showing 1 of 4 variants.

Variant ID.  77
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNlVATL
Mutations T/L
Epitope Location T5L
HXB2 Location T81L
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note To identify immunogenically optimized epitopes for use in vaccines, mutants of SL9 were tested in transgenic mice. SLYNTVATL and most common mutant, SLfNTVATL, were weakly immunogenic or cross-reactive. 3 mutants, SLYNlVATL, SLfNlVATL and SiYNlVATL were highly immunogenic. Peptide SiYNlVATL with the additional L2I change allowed great cross-reactivity to the consensus.


Blondelle2008 Sylvie E. Blondelle, Rosa Moya-Castro, Keiko Osawa, Kim Schroder, and Darcy B. Wilson. Immunogenically Optimized Peptides Derived from Natural Mutants of HIV CTL Epitopes and Peptide Combinatorial Libraries. Biopolymers, 90(5):683-694, 2008. PubMed ID: 18481808. Show all entries for this paper.

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