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Found 1 matching record:

Displaying record number 53745

HXB2 Location  Gag(167-175)   Gag Epitope Map
View variants at this location
Epitope EVIPMFSAL   Epitope Alignment
Variants
EVIPMFtAL   escape documented in this paper; TCR related mutation
Species (MHC/HLA human(A*26:01, A*26:03)

Variant Details

Showing 1 of 16 variants.


Variant ID.  684
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPMFtAL
Mutations S/T
Epitope Location S7T
HXB2 Location S173T
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Epitope Subtype A, B, CRF01_AE, D
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note Variant bound to A*2603 with equal affinity as the consensus form but could not be recognized by an EVIPMFSAL-specific T-cell clone, so it may mediate TCR escape

References

Kawashima2005 Yuka Kawashima, Manami Satoh, Shinichi Oka, and Masafumi Takiguchi. Identification and Characterization of HIV-1 Epitopes Presented by HLA-A*2603: Comparison Between HIV-1 Epitopes Presented by A*2601 and A*2603. Hum. Immunol., 66(11):1155-1166, Nov 2005. PubMed ID: 16571416. Show all entries for this paper.


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