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Displaying record number 53745

HXB2 Location Gag(167-175) Gag Epitope Map
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Epitope

EVIPMFSAL

Epitope Alignment

Variants

EVIPMFaAL escape documented in this paper; TCR related mutation

Species (MHC/HLA) human(A*26:01, A*26:03)

Variant Details

Showing 1 of 16 variants.

Variant ID.	`683`
Epitope Seq.	`EVIPMFSAL`
Variant Seq.	`EVIPMFaAL`
Mutations	S/A
Epitope Location	S7A
HXB2 Location	S173A
Mutation Type	E: escape documented in this paper TCR: TCR related mutation
Method	CD8 T-cell Elispot - IFNy
Note	Variant bound to A*2603 with equal affinity as the consensus form but could not be recognized by an EVIPMFSAL-specific T-cell clone, so it may mediate TCR escape

References

Kawashima2005 Yuka Kawashima, Manami Satoh, Shinichi Oka, and Masafumi Takiguchi. Identification and Characterization of HIV-1 Epitopes Presented by HLA-A*2603: Comparison Between HIV-1 Epitopes Presented by A*2601 and A*2603. Hum. Immunol., 66(11):1155-1166, Nov 2005. PubMed ID: 16571416. Show all entries for this paper.