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Found 1 matching record:

Displaying record number 54579

HXB2 Location  Gag(93-101)   Gag Epitope Map
View variants at this location
Epitope EVKDTKEAL   Epitope Alignment
Variants
dVKDTKEAL   diminished response
Epitope Name EL9
Species (MHC/HLA human(B*08)

Variant Details

Showing 1 of 4 variants.


Variant ID.  637
Epitope Seq.  EVKDTKEAL
Variant Seq.  dVKDTKEAL
Mutations E/D
Epitope Location E1D
HXB2 Location E93D
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Variant found in one patient at week 63. A minor response to this variant, but the variant was eliminated by CTLs. R91G upstream mutation affects processing.

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


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