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Displaying record number 54556

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTiATL   diminished response; escape documented in this paper
Epitope Name SL9
Species (MHC/HLA human(A*02)

Variant Details

Showing 1 of 4 variants.


Variant ID.  634
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiATL
Mutations Y/F V/I
Epitope Location Y3F V6I
HXB2 Location Y79F V82I
Mutation Type DR: diminished response
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant detected by week 63. Lower magnitude responses than wt and V/I mutant. Positive selection. Seen with upstream changes E62G/V/A, where the 62A mutation persisted and is suggested to reduce fitness cost of the Y/F escape mutation.

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


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