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Found 1 matching record:

Displaying record number 53603

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTIATL   Epitope Alignment
Variants
SLYNTIAvL   susceptible form
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing 1 of 2 variants.


Variant ID.  60
Epitope Seq.  SLYNTIATL
Variant Seq.  SLYNTIAvL
Mutations T/V
Epitope Location T8V
HXB2 Location T84V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining
Note The response to this variant peptide, SVL9, was not apparent until month 20, by month 32 a T to V change was dominant, but the SLYNTIAvL mutant showed comparable avidity.

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


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