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Displaying record number 54497

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVATL

Epitope Alignment

Variants

SLYNTVAaL susceptible form

Epitope Name SL9

Species (MHC/HLA) human, mouse(A2)

Variant Details

Showing 1 of 29 variants.

Variant ID.	`596`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAaL`
Mutations	T/A
Epitope Location	T8A
HXB2 Location	T84A
Mutation Type	SF: susceptible form
Note	This synthesized variant was recognized by CTLs from 8/9 individuals. The variant was more immunogenic than the wt, reduced IL-2-mediated activation induced cell death that the wt CTLs were susceptible to, and induced broad response to several SL9 variants.

References

Kan-Mitchell2006 June Kan-Mitchell, Melissa Bajcz, Keri L. Schaubert, David A. Price, Jason M. Brenchley, Tedi E. Asher, Daniel C. Douek, Hwee L. Ng, Otto O. Yang, Charles R. Rinaldo, Jr., Jose Miguel Benito, Brygida Bisikirska, Ramakrishna Hegde, Franco M. Marincola, César Boggiano, Dianne Wilson, Judith Abrams, Sylvie E. Blondelle, and Darcy B. Wilson. Degeneracy and Repertoire of the Human HIV-1 Gag p17(77-85) CTL Response. J. Immunol., 176(11):6690-6701, 1 Jun 2006. PubMed ID: 16709828. Show all entries for this paper.