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Found 1 matching record:

Displaying record number 53602

HXB2 Location  Gag(20-28)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKKq   escape documented in this paper
Epitope Name RK9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  59
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKq
Mutations K/Q
Epitope Location K9Q
HXB2 Location K28Q
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining
Note Drastically reduced avidity. The response to this peptide was not apparent until month 20, by month 32 the escape variant was present.

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


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