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Displaying record number 53602

HXB2 Location Gag(20-28) Gag Epitope Map
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Epitope

RLRPGGKKK

Epitope Alignment

Variants

RLRPGGKKq escape documented in this paper

Epitope Name RK9

Species (MHC/HLA) human(A*03:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`59`
Epitope Seq.	`RLRPGGKKK`
Variant Seq.	`RLRPGGKKq`
Mutations	K/Q
Epitope Location	K9Q
HXB2 Location	K28Q
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining
Note	Drastically reduced avidity. The response to this peptide was not apparent until month 20, by month 32 the escape variant was present.

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.