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Found 1 matching record:

Displaying record number 53593

HXB2 Location  Gag(153-163)   Gag Epitope Map
View variants at this location
Epitope NAWVKVVEEKA   Epitope Alignment
Variants
NAWVKViEEKA   diminished response; subtype-specific susceptible form
Epitope Name Gag 8.4
Species (MHC/HLA macaque

Variant Details

Showing all: 1 variant(s).


Variant ID.  56
Epitope Seq.  NAWVKVVEEKA
Variant Seq.  NAWVKViEEKA
Mutations V/I
Epitope Location V7I
HXB2 Location V159I
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype CRF02_AG
Method Intracellular cytokine staining, T-cell Elispot
Note The B clade immune response to NAWVKVVEEKA gives a diminished response to the CRF02 variant NAWVKViEEKA, but does cross-react.

References

Amara2005a Rama Rao Amara, Sunita Sharma, Milloni Patel, James M. Smith, Lakshmi Chennareddi, James G Herndon, and Harriet L. Robinson. Studies on the Cross-Clade and Cross-Species Conservation of HIV-1 Gag-Specific CD8 and CD4 T Cell Responses Elicited by a Clade B DNA/MVA Vaccine in Macaques. Virology, 334(1):124-133, 30 Mar 2005. PubMed ID: 15749128. Show all entries for this paper.


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