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Found 1 matching record:

Displaying record number 53224

HXB2 Location  Gag(124-133)   Gag Epitope Map
View variants at this location
Epitope NSSQVSQNYP   Epitope Alignment
Variants
NSSkVSQNYP   diminished response
Epitope Name Gag NP10
Species (MHC/HLA human

Variant Details

Showing 1 of 11 variants.


Variant ID.  525
Epitope Seq.  NSSQVSQNYP
Variant Seq.  NSSkVSQNYP
Mutations Q/K
Epitope Location Q4K
HXB2 Location Q127K
Mutation Type DR: diminished response
Note Confirmed some degree of escape by diminishing CTL response.

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.

Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.


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