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Displaying record number 53741

HXB2 Location Gag(162-172) Gag Epitope Map
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Epitope

KAFSPEVIPMF

Epitope Alignment

Variants

KtFSPEVIPMF observed variant

Epitope Name KAF

Species (MHC/HLA) human(B57)

Variant Details

Showing 1 of 3 variants.

Variant ID.	`504`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KtFSPEVIPMF`
Mutations	A/T
Epitope Location	A2T
HXB2 Location	A163T
Mutation Type	OV: observed variant
Note	Variant was found in 1/5 B57+ individuals, but was always in a minor form. The frequency of the epitope mutation did not correlate with the percentage of IFN-gamma producing CTLs.

References

Jansen2005a Christine A. Jansen, Stefan Kostense, Kristin Vandenberghe, Nening M. Nanlohy, Iris M. De Cuyper, Erwan Piriou, Erik H. Manting, Frank Miedema, and Debbie van Baarle. High Responsiveness of HLA-B57-Restricted Gag-Specific CD8+ T Cells In Vitro May Contribute to the Protective Effect of HLA-B57 in HIV-Infection. Eur. J. Immunol., 35(1):150-158, Jan 2005. PubMed ID: 15593302. Show all entries for this paper.