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Found 1 matching record:

Displaying record number 53741

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KtFSPEVIPMF   observed variant
Epitope Name KAF
Species (MHC/HLA human(B57)

Variant Details

Showing 1 of 3 variants.


Variant ID.  504
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KtFSPEVIPMF
Mutations A/T
Epitope Location A2T
HXB2 Location A163T
Mutation Type OV: observed variant
Note Variant was found in 1/5 B57+ individuals, but was always in a minor form. The frequency of the epitope mutation did not correlate with the percentage of IFN-gamma producing CTLs.

References

Jansen2005a Christine A. Jansen, Stefan Kostense, Kristin Vandenberghe, Nening M. Nanlohy, Iris M. De Cuyper, Erwan Piriou, Erik H. Manting, Frank Miedema, and Debbie van Baarle. High Responsiveness of HLA-B57-Restricted Gag-Specific CD8+ T Cells In Vitro May Contribute to the Protective Effect of HLA-B57 in HIV-Infection. Eur. J. Immunol., 35(1):150-158, Jan 2005. PubMed ID: 15593302. Show all entries for this paper.


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