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Found 1 matching record:

Displaying record number 53008

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTVAvL   diminished HLA binding or increased off-rate; escape documented in this paper
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing 1 of 7 variants.


Variant ID.  492
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAvL
Mutations T/V
Epitope Location T8V
HXB2 Location T84V
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Note This variant was found in three patients and elicited <50% the response to the wt in two patients. Likely mechanism of escape was loss of HLA binding.

References

Jamieson2003 Beth D. Jamieson, Otto O. Yang, Lance Hultin, Mary Ann Hausner, Patricia Hultin, Jose Matud, Kevin Kunstman, Scott Killian, John Altman, Kristina Kommander, Bette Korber, Janis Giorgi, and Steven Wolinsky. Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J. Immunol., 171(10):5372-5379, 15 Nov 2003. PubMed ID: 14607940. Show all entries for this paper.


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