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Found 1 matching record:

Displaying record number 53008

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTiAvL   escape documented in this paper; TCR related mutation
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing 1 of 7 variants.


Variant ID.  490
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiAvL
Mutations V/I T/V
Epitope Location V6I T8V
HXB2 Location V82I T84V
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Note This variant was found in two patients and elicited <50% the response to the index peptide in both patients. The likely mechanism of escape was loss of T cell recognition.

References

Jamieson2003 Beth D. Jamieson, Otto O. Yang, Lance Hultin, Mary Ann Hausner, Patricia Hultin, Jose Matud, Kevin Kunstman, Scott Killian, John Altman, Kristina Kommander, Bette Korber, Janis Giorgi, and Steven Wolinsky. Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J. Immunol., 171(10):5372-5379, 15 Nov 2003. PubMed ID: 14607940. Show all entries for this paper.


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