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Found 1 matching record:

Displaying record number 53008

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTVATL   diminished HLA binding or increased off-rate; escape documented in this paper
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing 1 of 7 variants.


Variant ID.  486
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Note This variant was found in one patient and elicited <50% the response to the wt while it elicited strong response in another patient. Likely mechanism of escape was loss of HLA binding.

References

Jamieson2003 Beth D. Jamieson, Otto O. Yang, Lance Hultin, Mary Ann Hausner, Patricia Hultin, Jose Matud, Kevin Kunstman, Scott Killian, John Altman, Kristina Kommander, Bette Korber, Janis Giorgi, and Steven Wolinsky. Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J. Immunol., 171(10):5372-5379, 15 Nov 2003. PubMed ID: 14607940. Show all entries for this paper.


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