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Found 1 matching record:

Displaying record number 54498

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTiAvL   escape documented in this paper; TCR related mutation
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 19 variants.


Variant ID.  472
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiAvL
Mutations Y/F V/I T/V
Epitope Location Y3F V6I T8V
HXB2 Location Y79F V82I T84V
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Note Positively selected escape variant present in 7% of A2+ patients. HLA-binding affinity was sufficient to elicit CTL responses but the responses were usually weaker than to other variants. Assumed to impair TCR binding.

References

Iversen2006 Astrid K. N. Iversen, Guillaume Stewart-Jones, Gerald H. Learn, Natasha Christie, Christina Sylvester-Hviid, Andrew E. Armitage, Rupert Kaul, Tara Beattie, Jean K. Lee, Yanping Li, Pojchong Chotiyarnwong, Tao Dong, Xiaoning Xu, Mark A. Luscher, Kelly MacDonald, Henrik Ullum, Bente Klarlund-Pedersen, Peter Skinhøj, Lars Fugger, Søren Buus, James I. Mullins, E. Yvonne Jones, P. Anton van der Merwe, and Andrew J. McMichael. Conflicting Selective Forces Affect T Cell Receptor Contacts in an Immunodominant Human Immunodeficiency Virus Epitope. Nat. Immunol., 7(2):179-189, Feb 2006. PubMed ID: 16388312. Show all entries for this paper.


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