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Displaying record number 54498

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVATL

Epitope Alignment

Variants

SLYNTiATL non-susceptible form; susceptible form

Epitope Name SL9

Species (MHC/HLA) human(A2)

Variant Details

Showing 1 of 19 variants.

Variant ID.	`467`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiATL`
Mutations	V/I
Epitope Location	V6I
HXB2 Location	V82I
Mutation Type	NSF: non-susceptible form SF: susceptible form
Note	Variant present in 8% of 76 A2+ patients. Bound strongly to HLA-A2 (binding affinity was 94 nM). Was recognized by some A2+ patient's PBMCs and not recognized by others.

References

Iversen2006 Astrid K. N. Iversen, Guillaume Stewart-Jones, Gerald H. Learn, Natasha Christie, Christina Sylvester-Hviid, Andrew E. Armitage, Rupert Kaul, Tara Beattie, Jean K. Lee, Yanping Li, Pojchong Chotiyarnwong, Tao Dong, Xiaoning Xu, Mark A. Luscher, Kelly MacDonald, Henrik Ullum, Bente Klarlund-Pedersen, Peter Skinhøj, Lars Fugger, Søren Buus, James I. Mullins, E. Yvonne Jones, P. Anton van der Merwe, and Andrew J. McMichael. Conflicting Selective Forces Affect T Cell Receptor Contacts in an Immunodominant Human Immunodeficiency Virus Epitope. Nat. Immunol., 7(2):179-189, Feb 2006. PubMed ID: 16388312. Show all entries for this paper.