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Found 1 matching record:

Displaying record number 62490

HXB2 Location  Gag(156-165)   Gag Epitope Map
View variants at this location
Epitope VKVIEEKAF{S}   Epitope Alignment
Variants
VKVIEqKAF{N}   observed variant; susceptible form
Epitope Name VF9156-164
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  4457
Epitope Seq.  VKVIEEKAF{S}
Variant Seq.  VKVIEqKAF{N}
Mutations S/N E/Q
Epitope Location S10N E6Q
HXB2 Location S165N E161Q
Mutation Type OV: observed variant
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence
Note Mutations E161Q/S165N awere fixed to completion (100%) by 670d post-screening, indicating strong selection. No T-cell- or Ab-responses were detected against the mutant, and it was not a cryptic epitope, showing host-specific, non-adaptive immune selection pressures.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.


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