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Displaying record number 62488

HXB2 Location Gag(36-44) Gag Epitope Map
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Epitope

WASRELEKF

Epitope Alignment

Variants

WASRELErF observed variant; replicative capacity reduced; susceptible form

Epitope Name WF936-44

Species (MHC/HLA) human(B*35)

Variant Details

Showing 1 of 2 variants.

Variant ID.	`4454`
Epitope Seq.	`WASRELEKF`
Variant Seq.	`WASRELErF`
Mutations	K/R
Epitope Location	K8R
HXB2 Location	K43R
Mutation Type	OV: observed variant RCR: replicative capacity reduced SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Relative replication capacity assay
Note	Mutation K43R appeared at 91d post-screening, and was fixed by 175d post-screening by which time it was predominant (83%), indicating strong selection. No T-cell- or Ab-responses were detected against the mutant, and it was not a cryptic epitope, showing host-specific, non-adaptive immune selection pressures. The mutant was shown to be 12% less fit than the T/F virus over 3 comparative fitness passages until it was almost completely replaced by the T/F.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.