HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 62488

HXB2 Location  Gag(36-44)   Gag Epitope Map
View variants at this location
Epitope WASRELEKF   Epitope Alignment
WASRELErF   observed variant; replicative capacity reduced; susceptible form
Epitope Name WF936-44
Species (MHC/HLA human(B*35)

Variant Details

Showing 1 of 2 variants.

Variant ID.  4454
Epitope Seq.  WASRELEKF
Variant Seq.  WASRELErF
Mutations K/R
Epitope Location K8R
HXB2 Location K43R
Mutation Type OV: observed variant
RCR: replicative capacity reduced
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Relative replication capacity assay
Note Mutation K43R appeared at 91d post-screening, and was fixed by 175d post-screening by which time it was predominant (83%), indicating strong selection. No T-cell- or Ab-responses were detected against the mutant, and it was not a cryptic epitope, showing host-specific, non-adaptive immune selection pressures. The mutant was shown to be 12% less fit than the T/F virus over 3 comparative fitness passages until it was almost completely replaced by the T/F.


Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.

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