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Displaying record number 62302

HXB2 Location  Gag(203-212)   Gag Epitope Map
View variants at this location
Epitope ETINEEAAEW   Epitope Alignment
Variants
ETINEEAAEW{DRl}   observed variant; replicative capacity is not abrogated; susceptible form
Epitope Name EW10
Species (MHC/HLA human(A*25)

Variant Details

Showing 1 of 3 variants.


Variant ID.  4407
Epitope Seq.  ETINEEAAEW{DRV}
Variant Seq.  ETINEEAAEW{DRl}
Mutations V/L
Epitope Location V13L
HXB2 Location V215L
Mutation Type OV: observed variant
RCOK: replicative capacity is not abrogated
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other, Sequence
Note Variant V215L is actually the HIV-B strain consensus position but was not autologous in these studies. V215L had a greater fitness in ex-vivo studies than the autologous 215V. It was seen in patients 1362 at 769 DPS onwards, patient PIC1349 between 44 and 342 DPS, and PIC1052 between 184 and 754 DPS.

References

Troyer2009 Ryan M. Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W. Krizan, Awet Abraha, Denis M. Tebit, Hong Zhao, Santiago Avila, Michael A. Lobritz, M. Juliana McElrath, Sylvie Le Gall, James I. Mullins, and Eric J. Arts. Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response. PLoS Pathog., 5(4):e1000365, Apr 2009. PubMed ID: 19343217. Show all entries for this paper.


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