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Found 1 matching record:

Displaying record number 62250

HXB2 Location  Gag(145-155)   Gag Epitope Map
View variants at this location
Epitope QAISPRTLNAW   Epitope Alignment
Variants
QplSPtTLNAW   observed variant
Epitope Name QW11
Species (MHC/HLA human(A*25)

Variant Details

Showing 1 of 7 variants.


Variant ID.  4400
Epitope Seq.  QAISPRTLNAW
Variant Seq.  QplSPtTLNAW
Mutations A/P I/L R/T
Epitope Location A2P I3L R6T
HXB2 Location A146P I147L R150T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Relative replication capacity assay, Sequence
Note Triple mutant, QplSPtTLNAW, was seen only in patient PIC1349 at 2025 DPS (days post symptoms).

References

Troyer2009 Ryan M. Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W. Krizan, Awet Abraha, Denis M. Tebit, Hong Zhao, Santiago Avila, Michael A. Lobritz, M. Juliana McElrath, Sylvie Le Gall, James I. Mullins, and Eric J. Arts. Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response. PLoS Pathog., 5(4):e1000365, Apr 2009. PubMed ID: 19343217. Show all entries for this paper.


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