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Displaying record number 62250

HXB2 Location  Gag(145-155)   Gag Epitope Map
View variants at this location
Epitope QAISPRTLNAW   Epitope Alignment
Variants
QplSPRTLNAW   diminished response; escape documented in this paper; observed variant; replicative capacity reduced
Epitope Name QW11
Species (MHC/HLA human(A*25)

Variant Details

Showing 1 of 7 variants.


Variant ID.  4399
Epitope Seq.  QAISPRTLNAW
Variant Seq.  QplSPRTLNAW
Mutations A/P I/L
Epitope Location A2P I3L
HXB2 Location A146P I147L
Mutation Type DR: diminished response
E: escape documented in this paper
OV: observed variant
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Relative replication capacity assay, Sequence
Note Double mutant, QplSPRTLNAW, was seen in patient PIC1362 769 DPS (days post symptoms) onwards, and was an escape and with some fitness loss. In patient 1349, it was seen after 342 DPS. Ex vivo relative fitness was decreased for this double variant though the single variant (not found in autologous sequences), A146P had great fitness decrease, suggesting that I147L reverses this loss of fitness at position 2. The two mutations are linked.

References

Troyer2009 Ryan M. Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W. Krizan, Awet Abraha, Denis M. Tebit, Hong Zhao, Santiago Avila, Michael A. Lobritz, M. Juliana McElrath, Sylvie Le Gall, James I. Mullins, and Eric J. Arts. Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response. PLoS Pathog., 5(4):e1000365, Apr 2009. PubMed ID: 19343217. Show all entries for this paper.


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