HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(145-155)|| Gag Epitope Map
View variants at this location
Showing 1 of 7 variants.
|Epitope Location||A2P I3L|
|HXB2 Location||A146P I147L|
|Mutation Type||DR: diminished response
E: escape documented in this paper
OV: observed variant
RCR: replicative capacity reduced
|Method||CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Relative replication capacity assay, Sequence|
|Note||Double mutant, QplSPRTLNAW, was seen in patient PIC1362 769 DPS (days post symptoms) onwards, and was an escape and with some fitness loss. In patient 1349, it was seen after 342 DPS. Ex vivo relative fitness was decreased for this double variant though the single variant (not found in autologous sequences), A146P had great fitness decrease, suggesting that I147L reverses this loss of fitness at position 2. The two mutations are linked.|
Troyer2009 Ryan M. Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W. Krizan, Awet Abraha, Denis M. Tebit, Hong Zhao, Santiago Avila, Michael A. Lobritz, M. Juliana McElrath, Sylvie Le Gall, James I. Mullins, and Eric J. Arts. Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response. PLoS Pathog., 5(4):e1000365, Apr 2009. PubMed ID: 19343217. Show all entries for this paper.