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Displaying record number 52824

HXB2 Location Gag(20-28) Gag Epitope Map
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Epitope

RLRPGGKKK

Epitope Alignment

Variants

RLRPGGKKt diminished response

Epitope Name A3-RK9 Ga9

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`43`
Epitope Seq.	`RLRPGGKKK`
Variant Seq.	`RLRPGGKKt`
Mutations	K/T
Epitope Location	K9T
HXB2 Location	K28T
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant rlrpggkkT. The CTL response declined over time, and the response to the second variant was lower than to the first one

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.