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Displaying record number 62248

HXB2 Location  Gag(76-86)   Gag Epitope Map
View variants at this location
Epitope RSLYNTVATLY   Epitope Alignment
Variants
RSLYNTVvTLY   observed variant
Epitope Name Gag-RY11
Species (MHC/HLA human(A*30)

Variant Details

Showing 1 of 5 variants.


Variant ID.  4293
Epitope Seq.  RSLYNTVATLY
Variant Seq.  RSLYNTVvTLY
Mutations A/V
Epitope Location A8V
HXB2 Location A83V
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RSLYNTVvTLY (A83V) was observed to arise in A*30+ (which is a restricting HLA for RY11) subject 517-C between 2.5 and 5 years. It was always observed as a covariant with Y79F, T84V, and R76K. Sometimes it was also observed with V82I.

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


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