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Displaying record number 62248

HXB2 Location Gag(76-86) Gag Epitope Map
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Epitope

RSLYNTVATLY

Epitope Alignment

Variants

RSLYNTiATLY observed variant

Epitope Name Gag-RY11

Species (MHC/HLA) human(A*30)

Variant Details

Showing 1 of 5 variants.

Variant ID.	`4292`
Epitope Seq.	`RSLYNTVATLY`
Variant Seq.	`RSLYNTiATLY`
Mutations	V/I
Epitope Location	V7I
HXB2 Location	V82I
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RSLYNTiATLY (V82I) was observed to arise in A*30⁺ (which is a restricting HLA for RY11) subject 517-C between 2.5 and 5 years. It was always observed as a covariant with Y79F, T84V, and R76K. Sometimes it was also observed with A83V.

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.