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Found 1 matching record:

Displaying record number 61683

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPQDLNmML   literature escape
Epitope Name Gag-TL9
Species (MHC/HLA human(B*81:01)

Variant Details

Showing 1 of 4 variants.


Variant ID.  4251
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNmML
Mutations T/M
Epitope Location T7M
HXB2 Location T186M
Mutation Type LE: literature escape
Epitope Subtype C
Variant Subtype C
Method Sequence
Note TPQDLNmML (T186X) is a documented escape variant. It was observed to arise between 0.7 and 1.3yrs in B*81+ (which is a restricting HLA for TL9) subject 133-C.

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


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