HIV molecular immunology database
Found 1 matching record:
HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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Epitope |
TPQDLNTML
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Epitope Alignment | ||||
Variants |
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Epitope Name | Gag-TL9 | |||||
Species (MHC/HLA) | human(B*81:01) |
Showing 1 of 4 variants.
Variant ID. | 4251 |
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Epitope Seq. | TPQDLNTML |
Variant Seq. | TPQDLNmML |
Mutations | T/M |
Epitope Location | T7M |
HXB2 Location | T186M |
Mutation Type | LE: literature escape |
Epitope Subtype | C |
Variant Subtype | C |
Method | Sequence |
Note | TPQDLNmML (T186X) is a documented escape variant. It was observed to arise between 0.7 and 1.3yrs in B*81+ (which is a restricting HLA for TL9) subject 133-C. |
Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.