HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(6-15) | Gag Epitope Map
View variants at this location |
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| Epitope |
SILRGGKLDK
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | Gag-SK10 | |||||
| Species (MHC/HLA) | human(A*74:01) | |||||
Showing 1 of 3 variants.
| Variant ID. | 4232 |
|---|---|
| Epitope Seq. | SILRGGKLDK |
| Variant Seq. | SILRGGnLDK |
| Mutations | K/N |
| Epitope Location | K7N |
| HXB2 Location | K12N |
| Mutation Type | LE: literature escape |
| Epitope Subtype | C |
| Variant Subtype | C |
| Method | Sequence |
| Note | SILRGGnLDK is a known escape variant. While SILRGGnLDK does not appear to have been transmitted to 133-C from the A*74- (which is the restricting HLA for SK10) mother, it arose in the child and was observed to be at a frequency of 100% at 0.3yr. In 133-C, A*74+, the K12N mutation was always observed as a co-variant with G11E and sometimes covariant with I7V. |
Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.