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Found 1 matching record:

Displaying record number 61685

HXB2 Location  Gag(6-15)   Gag Epitope Map
View variants at this location
Epitope SILRGGKLDK   Epitope Alignment
Variants
SILRGGnLDK   literature escape
Epitope Name Gag-SK10
Species (MHC/HLA human(A*74:01)

Variant Details

Showing 1 of 3 variants.


Variant ID.  4232
Epitope Seq.  SILRGGKLDK
Variant Seq.  SILRGGnLDK
Mutations K/N
Epitope Location K7N
HXB2 Location K12N
Mutation Type LE: literature escape
Epitope Subtype C
Variant Subtype C
Method Sequence
Note SILRGGnLDK is a known escape variant. While SILRGGnLDK does not appear to have been transmitted to 133-C from the A*74- (which is the restricting HLA for SK10) mother, it arose in the child and was observed to be at a frequency of 100% at 0.3yr. In 133-C, A*74+, the K12N mutation was always observed as a co-variant with G11E and sometimes covariant with I7V.

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


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