HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 107

HXB2 Location  Gag(84-91)   Gag Epitope Map
View variants at this location
Epitope TLYCVHQR   Epitope Alignment
TLYCVHQq   diminished response
Species (MHC/HLA human(A11)

Variant Details

Showing 1 of 3 variants.

Variant ID.  413
Epitope Seq.  TLYCVHQR
Variant Seq.  TLYCVHQq
Mutations R/Q
Epitope Location R8Q
HXB2 Location R91Q
Mutation Type DR: diminished response
Method Chromium-release assay
Note Variant found in patient. It was recognized by patient CTLs but less than the R/K variant, and only induced target specific lysis at high concentrations. This mutation did not abrogate virus replication.


Harrer1998 T. Harrer, E. Harrer, P. Barbosa, F. Kaufmann, R. Wagner, S. Bruggemann, J. R. Kalden, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. Recognition of Two Overlapping CTL Epitopes in HIV-1 p17 by CTL from a Long-Term Nonprogressing HIV-1-Infected Individual. J. Immunol., 161:4875-4881, 1998. PubMed ID: 9794421. Show all entries for this paper.

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