HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(124-132) | Gag Epitope Map
View variants at this location |
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| Epitope |
NSSQVSQNY
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | NY9, p17NY9 | |||||
| Species (MHC/HLA) | human(B*35:01) | |||||
Showing all: 1 variant(s).
| Variant ID. | 4124 |
|---|---|
| Epitope Seq. | NSSQVSQNY |
| Variant Seq. | NSgQVSQNY |
| Mutations | S/G |
| Epitope Location | S3G |
| HXB2 Location | S126G |
| Mutation Type | OV: observed variant RCOK: replicative capacity is not abrogated |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CTL suppression of replication, Intracellular cytokine staining, Tetramer binding |
| Note | Gag S126G, an HLA-A*1101-associated polymorphism is in the GagNY9 epitope, and did not accumulate in HLA-B*3501+ Japanese individuals. This mutation is selected by A*1101-restricted CTL and did not influence control of HIV-1 by B*3501-specific CTL. |
Murakoshi2018a Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, Takayuki Chikata, Nozomi Kuse, Hiroyuki Gatanaga, Sarah L. Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi. Impact of a Single HLA-A*24:02-Associated Escape Mutation on the Detrimental Effect of HLA-B*35:01 in HIV-1 Control. EBioMedicine, 36:103-112, Oct 2018. PubMed ID: 30249546. Show all entries for this paper.