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Found 1 matching record:

Displaying record number 61881

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPaDLNlML   non-susceptible form; observed variant
Epitope Name Gag TL9
Species (MHC/HLA human(B*67:01)

Variant Details

Showing 1 of 2 variants.


Variant ID.  4092
Epitope Seq.  TPQDLNTML
Variant Seq.  TPaDLNlML
Mutations Q/A T/L
Epitope Location Q3A T7L
HXB2 Location Q182A T186L
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note TPaDLNlML, TL9-3A7L is a variant of B*6701-restricted WT epitope TPQDLNTML. It is not recognized by TL9-specific CTL, but is found in 0.6% chronically HIV-1-infected Japanese patients and in none who are B*6701+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


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