Search the Epitope Variant and Escape Mutation Database

Help

Found 1 matching record:

Displaying record number 61629

HXB2 Location Gag(147-155) Gag Epitope Map
View variants at this location

Epitope

ISPRTLNAW

Epitope Alignment

Variants

xSPRTLNAW HLA association; literature escape; observed variant; subtype-specific non-susceptible form

Epitope Name ISW9

Species (MHC/HLA) human(B*57:03)

Variant Details

Showing 1 of 2 variants.

Variant ID.	`4021`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`xSPRTLNAW`
Mutations	I/X
Epitope Location	I1X
HXB2 Location	I147X
Mutation Type	A: HLA association LE: literature escape OV: observed variant SNSF: subtype-specific non-susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	Sequence
Note	Polymorphism at I147X, for escape xSPRTLNAW, was associated with HLA-B*5703 in B-infected subjects of the Barbados cohort.

References

Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.