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Displaying record number 61531

HXB2 Location Gag(39-46) Gag Epitope Map
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Epitope

RELERFAL

Epitope Alignment

Variants

RELERFAv subtype-specific susceptible form

Epitope Name Gag RV8-8L

Species (MHC/HLA) human(B*40:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3933`
Epitope Seq.	`RELERFAL`
Variant Seq.	`RELERFAv`
Mutations	L/V
Epitope Location	L8V
HXB2 Location	L46V
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	CRF01_AE
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note	B clade epitope RELERFAv was found in 4/26 A/E patients of the KI cohort, though it was found in 1299/1644 B virus and 20/315 clade A/E virus sequences in the Los Alamos HIV-1 database. It was recognized by CTL from clade A/E-infected patient KI-388 which had been elicited by consensus clade B RV8.

References

Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.