HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 61245

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPsDLNsML   HLA association; observed variant
Epitope Name TL9, TL9T7
Species (MHC/HLA human(B*42:01, B*81:01)

Variant Details

Showing 1 of 5 variants.


Variant ID.  3756
Epitope Seq.  TPQDLNTML
Variant Seq.  TPsDLNsML
Mutations Q/S T/S
Epitope Location Q3S T7S
HXB2 Location Q182S T186S
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B, C, D, F, G, J, K
Variant Subtype C
Method Other
Note Variant TL9S3S7, TPsDLNsML, is present in 2.5% of B*81-/B*42- subjects; 28.6% of B*81+; and 14.3% of B*42+ subjects.

References

Geldmacher2009 Christof Geldmacher, Ian S. Metzler, Sodsai Tovanabutra, Tedi E. Asher, Emma Gostick, David R. Ambrozak, Constantinos Petrovas, Alexandra Schuetz, Njabulo Ngwenyama, Gustavo Kijak, Leonard Maboko, Michael Hoelscher, Francine McCutchan, David A. Price, Daniel C. Douek, and Richard A. Koup. Minor Viral and Host Genetic Polymorphisms Can Dramatically Impact the Biologic Outcome of an Epitope-Specific CD8 T-Cell Response. Blood, 114(8):1553-1562, 20 Aug 2009. PubMed ID: 19542300. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health