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Found 1 matching record:

Displaying record number 61245

HXB2 Location  Gag(180-188)   Gag Epitope Map
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Epitope TPQDLNTML   Epitope Alignment
Variants
TPQDLNsML   HLA association; observed variant
Epitope Name TL9, TL9T7
Species (MHC/HLA human(B*42:01, B*81:01)

Variant Details

Showing 1 of 5 variants.


Variant ID.  3755
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNsML
Mutations T/S
Epitope Location T7S
HXB2 Location T186S
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B, C, D, F, G, J, K
Variant Subtype C
Method Other
Note Variant TL9S7, TPQDLNsML, is present in 5% of B*42-/B*81- subjects; 57.1% of B*81+ subjects. Thus T3S substitution is predominantly selected in the presence of B*81. A second substitution at Q3S is observed in association with coexpression of a second TL9 presenting allele, either B*07 or B*42. In 5/6 TL9S7 variant viruses, upstream E177D or downstream T190I/A were seen. Different substitutions at P3 were associated with presence of B*42 allele, where Q3T, Q3G, Q3A or Q3S were isolated from B*53 or B*81-expressing subjects.

References

Geldmacher2009 Christof Geldmacher, Ian S. Metzler, Sodsai Tovanabutra, Tedi E. Asher, Emma Gostick, David R. Ambrozak, Constantinos Petrovas, Alexandra Schuetz, Njabulo Ngwenyama, Gustavo Kijak, Leonard Maboko, Michael Hoelscher, Francine McCutchan, David A. Price, Daniel C. Douek, and Richard A. Koup. Minor Viral and Host Genetic Polymorphisms Can Dramatically Impact the Biologic Outcome of an Epitope-Specific CD8 T-Cell Response. Blood, 114(8):1553-1562, 20 Aug 2009. PubMed ID: 19542300. Show all entries for this paper.


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