HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(180-188)|| Gag Epitope Map
View variants at this location
|Epitope Name||TL9, TL9T7|
|Species (MHC/HLA)||human(B*42:01, B*81:01)|
Showing 1 of 5 variants.
|Mutation Type||A: HLA association
OV: observed variant
|Epitope Subtype||B, C, D, F, G, J, K|
|Note||Variant TL9S7, TPQDLNsML, is present in 5% of B*42-/B*81- subjects; 57.1% of B*81+ subjects. Thus T3S substitution is predominantly selected in the presence of B*81. A second substitution at Q3S is observed in association with coexpression of a second TL9 presenting allele, either B*07 or B*42. In 5/6 TL9S7 variant viruses, upstream E177D or downstream T190I/A were seen. Different substitutions at P3 were associated with presence of B*42 allele, where Q3T, Q3G, Q3A or Q3S were isolated from B*53 or B*81-expressing subjects.|
Geldmacher2009 Christof Geldmacher, Ian S. Metzler, Sodsai Tovanabutra, Tedi E. Asher, Emma Gostick, David R. Ambrozak, Constantinos Petrovas, Alexandra Schuetz, Njabulo Ngwenyama, Gustavo Kijak, Leonard Maboko, Michael Hoelscher, Francine McCutchan, David A. Price, Daniel C. Douek, and Richard A. Koup. Minor Viral and Host Genetic Polymorphisms Can Dramatically Impact the Biologic Outcome of an Epitope-Specific CD8 T-Cell Response. Blood, 114(8):1553-1562, 20 Aug 2009. PubMed ID: 19542300. Show all entries for this paper.