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Found 1 matching record:

Displaying record number 49

HXB2 Location  Gag(24-35)   Gag Epitope Map
View variants at this location
Epitope GGKKKYKLKHIV   Epitope Alignment
Variants
GrKKKYKLKHIV   escape documented in this paper
Species (MHC/HLA human(B8)

Variant Details

Showing 1 of 7 variants.


Variant ID.  374
Epitope Seq.  GGKKKYKLKHIV
Variant Seq.  GrKKKYKLKHIV
Mutations G/R
Epitope Location G2R
HXB2 Location G25R
Mutation Type E: escape documented in this paper
Note This variant failed to be recognized by CTLs and failed to induce target specific lysis.

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.


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