HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(162-172)|| Gag Epitope Map
View variants at this location
|Species (MHC/HLA)||human(B*57:01, B*57:03)|
Showing 1 of 4 variants.
|Mutation Type||DHB: diminished HLA binding or increased off-rate
DR: diminished response
E: escape documented in this paper
RCR: replicative capacity reduced
|Note||KgFSPEVIPMF, position-2 escape from KF11, results in a loss but not abrogation of HLA binding. The resulting VRC reduction is substantially reversed by compensatory S165N. Combination of A163G/S165N results in complete loss of epitope recognition by CTL.|
Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.