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Displaying record number 61203

HXB2 Location  Gag(180-188)   Gag Epitope Map
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Epitope TPQDLNTML   Epitope Alignment
Variants
TPQDLNsML   escape documented in this paper; replicative capacity reduced
Epitope Name TL9
Species (MHC/HLA human(B*07:02, B*39:10, B*42:01, B*81:01, C*08:02)

Variant Details

Showing 1 of 5 variants.


Variant ID.  3709
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNsML
Mutations T/S
Epitope Location T7S
HXB2 Location T186S
Mutation Type E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note B*8101-restricted TPsDLNTML is the most commonly selected escape variant of TPQDLNTML (25-30% of chronic patients) and substantially reduces VRC. No clear compensatory mutations have been identified.

References

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.


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