HIV molecular immunology database
Found 1 matching record:
HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
||||
---|---|---|---|---|---|---|
Epitope |
TPQDLNTML
|
Epitope Alignment | ||||
Variants |
|
|||||
Epitope Name | TL9 | |||||
Species (MHC/HLA) | human(B*07:02, B*39:10, B*42:01, B*81:01, C*08:02) |
Showing 1 of 5 variants.
Variant ID. | 3709 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPQDLNsML |
Mutations | T/S |
Epitope Location | T7S |
HXB2 Location | T186S |
Mutation Type | E: escape documented in this paper RCR: replicative capacity reduced |
Epitope Subtype | B |
Variant Subtype | B |
Method | Other |
Note | B*8101-restricted TPsDLNTML is the most commonly selected escape variant of TPQDLNTML (25-30% of chronic patients) and substantially reduces VRC. No clear compensatory mutations have been identified. |
Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.