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Found 1 matching record:

Displaying record number 61181

HXB2 Location  Gag(84-91)   Gag Epitope Map
View variants at this location
Epitope TMYCVHQK   Epitope Alignment
Variants
TlYCVHQK   diminished response; escape documented in this paper; non-susceptible form; susceptible form
Epitope Name TMK11
Species (MHC/HLA human(A*11:01)

Variant Details

Showing 1 of 3 variants.


Variant ID.  3682
Epitope Seq.  TMYCVHQK
Variant Seq.  TlYCVHQK
Mutations M/L
Epitope Location M2L
HXB2 Location M85L
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag TMK11 escape variant TlYCVHQK did not cross-react to autologous TMK11 (TMYCVHQK)-specific T cells during acute infection but did cross-react during chronic infection in A*1101 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


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