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Displaying record number 61181

HXB2 Location Gag(84-91) Gag Epitope Map
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Epitope

TMYCVHQK

Epitope Alignment

Variants

vlYCVHQr diminished response; escape documented in this paper; non-susceptible form

Epitope Name TMK11

Species (MHC/HLA) human(A*11:01)

Variant Details

Showing 1 of 3 variants.

Variant ID.	`3681`
Epitope Seq.	`TMYCVHQK`
Variant Seq.	`vlYCVHQr`
Mutations	T/V M/L K/R
Epitope Location	T1V M2L K8R
HXB2 Location	T84V M85L K91R
Mutation Type	DR: diminished response E: escape documented in this paper NSF: non-susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note	Gag TMK11 escape variant vlYCVHQr did not cross-react to autologous TMK11 (TMYCVHQK)-specific T cells during acute and chronic infection in A*1101 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.