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Found 1 matching record:

Displaying record number 60669

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope KYRLKHIVW   Epitope Alignment
Variants
rYrLKHlVW   observed variant; susceptible form
Species (MHC/HLA human(A*24:02)

Variant Details

Showing 1 of 2 variants.


Variant ID.  3552
Epitope Seq.  KYRLKHIVW
Variant Seq.  rYrLKHlVW
Mutations K/R I/L
Epitope Location K1R I7L
HXB2 Location K28R I34L
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Other
Note Contrary to most cases, autologous variant Gag rYRLKHlVW of subject S4 elicits a smaller CTL response from DC-primed naive T cells than DC-stimulated memory T cells.

References

Smith2016 Kellie N. Smith, Robbie B. Mailliard, Paolo A. Piazza, Will Fischer, Bette T. Korber, Ronald J. Fecek, Deena Ratner, Phalguni Gupta, James I. Mullins, and Charles R. Rinaldo. Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells. MBio, 7(3), 31 May 2016. PubMed ID: 27247230. Show all entries for this paper.


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