Found 1 matching record:
HXB2 Location | Gag(162-172) | Gag Epitope Map
View variants at this location |
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Epitope |
KAFSPEVIPMF
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Epitope Alignment | ||||
Variants |
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Epitope Name | KAFS | |||||
Species (MHC/HLA) | human(B*57:01, B*57:03) |
Showing 1 of 8 variants.
Variant ID. | 352 |
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Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KAFSqEVIPMF |
Mutations | P/Q |
Epitope Location | P5Q |
HXB2 Location | P166Q |
Mutation Type | DR: diminished response SSF: subtype-specific susceptible form |
Epitope Subtype | B |
Variant Subtype | AC |
Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding |
Note | Variant found in clade A /C. It induced IFN-gamma production in 3/6 patients' PBMC but it demonstrated a diminished capacity to sensitize target cells for lysis. This variant was a weak ligand. |
Gillespie2002 Geraldine M. A. Gillespie, Rupert Kaul, Tao Dong, Hong-Bing Yang, Tim Rostron, Job J. Bwayo, Peter Kiama, Tim Peto, Francis A. Plummer, Andrew J. McMichael, and Sarah L. Rowland-Jones. Cross-Reactive Cytotoxic T Lymphocytes against a HIV-1 P24 Epitope in Slow Progressors with B*57. AIDS, 16(7):961-972, 3 May 2002. PubMed ID: 11953462. Show all entries for this paper.
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