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Displaying record number 52191

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KAFSqEVIPMF   diminished response; subtype-specific susceptible form
Epitope Name KAFS
Species (MHC/HLA human(B*57:01, B*57:03)

Variant Details

Showing 1 of 8 variants.


Variant ID.  352
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSqEVIPMF
Mutations P/Q
Epitope Location P5Q
HXB2 Location P166Q
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype AC
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding
Note Variant found in clade A /C. It induced IFN-gamma production in 3/6 patients' PBMC but it demonstrated a diminished capacity to sensitize target cells for lysis. This variant was a weak ligand.

References

Gillespie2002 Geraldine M. A. Gillespie, Rupert Kaul, Tao Dong, Hong-Bing Yang, Tim Rostron, Job J. Bwayo, Peter Kiama, Tim Peto, Francis A. Plummer, Andrew J. McMichael, and Sarah L. Rowland-Jones. Cross-Reactive Cytotoxic T Lymphocytes against a HIV-1 P24 Epitope in Slow Progressors with B*57. AIDS, 16(7):961-972, 3 May 2002. PubMed ID: 11953462. Show all entries for this paper.


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