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Found 1 matching record:

Displaying record number 52191

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KAFnPEiIPMF   subtype-specific susceptible form
Epitope Name KAFS
Species (MHC/HLA human(B*57:01, B*57:03)

Variant Details

Showing 1 of 8 variants.


Variant ID.  350
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFnPEiIPMF
Mutations S/N V/I
Epitope Location S4N V7I
HXB2 Location S165N V168I
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype O group
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding
Note Variant found in group O. It was recognized by CTLs and induced lysis of peptide-pulsed targets. The variant induced IFN-gamma secretion in PBMCs from 4 patients and did not induce secretion in PBMCs from 2 patients.

References

Gillespie2002 Geraldine M. A. Gillespie, Rupert Kaul, Tao Dong, Hong-Bing Yang, Tim Rostron, Job J. Bwayo, Peter Kiama, Tim Peto, Francis A. Plummer, Andrew J. McMichael, and Sarah L. Rowland-Jones. Cross-Reactive Cytotoxic T Lymphocytes against a HIV-1 P24 Epitope in Slow Progressors with B*57. AIDS, 16(7):961-972, 3 May 2002. PubMed ID: 11953462. Show all entries for this paper.


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