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Displaying record number 52191

HXB2 Location Gag(162-172) Gag Epitope Map
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Epitope

KAFSPEVIPMF

Epitope Alignment

Variants

KAFSPEVIPvF subtype-specific susceptible form

Epitope Name KAFS

Species (MHC/HLA) human(B*57:01, B*57:03)

Variant Details

Showing 1 of 8 variants.

Variant ID.	`349`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFSPEVIPvF`
Mutations	M/V
Epitope Location	M10V
HXB2 Location	M171V
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	B
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding
Note	Variant found in clade A. It was recognized by CTLs and induced lysis of peptide-pulsed targets. The variant induced IFN-gamma secretion in PBMCs from all patients.

References

Gillespie2002 Geraldine M. A. Gillespie, Rupert Kaul, Tao Dong, Hong-Bing Yang, Tim Rostron, Job J. Bwayo, Peter Kiama, Tim Peto, Francis A. Plummer, Andrew J. McMichael, and Sarah L. Rowland-Jones. Cross-Reactive Cytotoxic T Lymphocytes against a HIV-1 P24 Epitope in Slow Progressors with B*57. AIDS, 16(7):961-972, 3 May 2002. PubMed ID: 11953462. Show all entries for this paper.