HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 59314

HXB2 Location  Gag(22-30)   Gag Epitope Map
View variants at this location
Epitope RPGGKKHYM   Epitope Alignment
RPGGKKsYM   diminished response; escape documented in this paper; observed variant
Epitope Name Gag-RM9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing 1 of 5 variants.

Variant ID.  3479
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKsYM
Mutations H/S
Epitope Location H7S
HXB2 Location H28S
Mutation Type DR: diminished response
E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 6% of B*4201+ and 2% of B*4201- subjects (n=1765) carried this escape variant, RPGGKKsYM.


Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.

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